產(chǎn)品詳情介紹
白介素-15（Interleukin-15， IL-15）是一種廣泛表達(dá)的細(xì)胞因子，在結(jié)構(gòu)和功能上與IL-2相關(guān)，在許多免疫疾病中發(fā)揮重要作用[1]。IL-15以高親和力結(jié)合IL-15 Rα，它們共同表達(dá)在細(xì)胞表面[2-3]。IL-15誘導(dǎo)或增強(qiáng)多種T細(xì)胞亞群的分化、維持或激活，包括NK、NKT、Th17、Treg和CD8+記憶細(xì)胞。在干細(xì)胞培養(yǎng)方案中，IL-15可與IL-21等其他細(xì)胞因子聯(lián)合使用，以提高NK細(xì)胞擴(kuò)增和成熟的效率[4]。
[1] Di Sabatino A, Calarota SA, Vidali F, MacDonald TT, Corazza GR. Role of IL-15 in immune-mediated and infectious diseases. Cytokine Growth Factor Rev, 2011, 22:19-33.
[2] Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K, et al. Identification and cloning of a novel IL-15 binding-protein that is structurally related to the alpha-chain of the Il-2 receptor. EMBO J, 1995, 14(15):3654-63.
[3] Dubois S, Mariner J, Waldmann TA, and Tagaya Y. IL-15 Ralpha recycles and presents IL-15 In trans to neighboring cells. Immunity, 2002, 17:537-547.
[4] Oberoi P, Kamenjarin K, Ossa JFV, Uherek B, B?nig H, and Wels WS. Directed Differentiation of Mobilized Hematopoietic Stem and Progenitor Cells into Functional NK cells with Enhanced Antitumor Activity. Cells, 2020, 9:811.
